Dr. Guinjoan is certified by the American Board of Psychiatry and Neurology in general psychiatry. He is currently Chief of Psychiatry (Children, Adolescents and Adults) at FLENI Foundation, a private, non-for-profit tertiary level care devoted to all branches of clinical neuroscience, and affiliated with the University of Buenos Aires’, Department of Psychiatry and Mental Health.
He graduated from medical school at the University of Buenos Aires in 1992, and got his Ph.D. at the Dept. of Physiology in 1995. He completed his residency in general psychiatry at the Sheppard Pratt/University of Maryland program, where he also was chief resident. He was awarded the “Clarence G. Shultz” prize, Sheppard Pratt Scientific Day, and the “1999- Resident of the Year,” among other awards.
Dr. Guinjoan is a consultant at Washington Behavioral Medicine Associates, LLC. His primary interests are Alzheimer’s Disease, mood, psychotic and other neuropsychiatric disorders.
Key Research Publications
Below are select publications that directly inform the evidence-based approaches available at WBMA. Each represents Dr. Guinjoan’s contribution to advancing the neurobiological understanding and treatment of mood, psychotic, and neuropsychiatric disorders.
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Reversible modulation of a deep white matter surgical target for depression with low-intensity focused ultrasound
Neuropsychopharmacology, 2025 – A randomized, sham-controlled study examining whether low-intensity focused ultrasound may modulate deep brain white matter tracts implicated in treatment-resistant depression – representing Dr. Guinjoan’s current research into non-invasive neuromodulation approaches for patients who have not responded to standard therapies. | View Publication
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Cognitive effects of rapid-acting treatments for resistant depression: Just adverse, or contributing to clinical efficacy?
Journal of Psychiatric Research, 2021 – A clinical analysis examining the cognitive profile of rapid-acting treatments for depression, including ketamine and electroconvulsive therapy, and how those cognitive effects may relate to – rather than simply detract from – their therapeutic impact in patients with resistant depression. | View Publication
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Childhood adversity modulation of central autonomic network components during cognitive regulation of emotion in major depressive disorder and borderline personality disorder
Psychiatry Research: Neuroimaging, 2021 – A neuroimaging study exploring how early adverse experiences may shape the brain’s autonomic and emotion regulation networks differently in major depression compared to borderline personality disorder – informing more individualized approaches to psychiatric assessment and treatment planning. | View Publication
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Distinct neural processing of acute stress in major depression and borderline personality disorder
Journal of Affective Disorders, 2021 – A functional neuroimaging study identifying differences in how the brain responds to acute psychological stress in patients with major depression versus borderline personality disorder, contributing to a more precise understanding of the neural signatures underlying each condition. | View Publication
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Real-time fMRI functional connectivity neurofeedback reducing repetitive negative thinking in depression: a double-blind, randomized, sham-controlled proof-of-concept trial
Translational Psychiatry, 2023 – A proof-of-concept trial exploring whether real-time brain connectivity neurofeedback may help reduce repetitive negative thinking – a key feature of depression – opening a potential avenue for non-pharmacological intervention in patients seeking alternatives to medication. | View Publication
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Abnormal brain network community structure related to psychological stress in schizophrenia
Schizophrenia Research, 2023 – A study examining how brain network organization may be disrupted in schizophrenia in relation to psychological stress responses, contributing to the understanding of stress sensitivity as a neurobiological feature with implications for treatment and monitoring. | View Publication
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Pattern of brain activation during social cognitive tasks is related to social competence in siblings discordant for schizophrenia
Journal of Psychiatric Research, 2014 – A neuroimaging study of siblings discordant for schizophrenia, examining how patterns of brain activation during social cognition relate to real-world social functioning – research with implications for identifying neurocognitive markers and informing functional rehabilitation approaches. | View Publication
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Wavelet transform shows age-related changes of heart rate variability within independent frequency components
Autonomic Neuroscience, 2010 – A psychophysiological study using advanced signal analysis to characterize how cardiac autonomic function changes across the lifespan, part of Dr. Guinjoan’s foundational research linking autonomic nervous system dysregulation to psychiatric and neuropsychiatric conditions. | View Publication
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Nonlinear analysis of heart rate variability within independent frequency components during the sleep-wake cycle
Autonomic Neuroscience, 2005 – A foundational study characterizing the nonlinear dynamics of cardiac autonomic regulation across sleep and wakefulness, contributing to a broader understanding of how disrupted autonomic function may serve as a physiological marker in mood and neuropsychiatric disorders. | View Publication
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Relation of depression to heart rate nonlinear dynamics in patients aged 60 years or older with recent unstable angina pectoris or acute myocardial infarction
American Journal of Cardiology, 2004 – A prospective study examining the connection between depressive symptoms and cardiac autonomic dysfunction in older adults following an acute coronary event – early research that helped establish the physiological pathway linking depression to adverse cardiovascular outcomes. | View Publication
